A Sodium Oxalate-Rich Diet Induces Chronic Kidney Disease and Cardiac Dysfunction in Rats.

After a dose–response study, which allowed us to choose an oxalate concentration of 50 μmol/g ( Figure A1 ), all of our experiments were performed on males, excluding one comparative experiment that may have shown that both male and females were sensitive to the OXA diet; this is despite there not being a significant trend for more severe phenotypes in females ( Figure A2 ), suggesting that gender does not influence oxalate nephrotoxicity, which is a major advantage of our protocol.

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It is possible that, by controlling access to an oxalate diet or using oral administration of OXA by gavage, the parameters that presented a statistical trend could in fact be significantly different.

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