Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study.

PLoS One · 2021 · PMC8432854 · PMID 34506535

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a negative trendno p-value reported

Notably, both the need for respiratory support and testing positive for COVID-19 showed a negative trend of association with HRT use, although the results were not nominally significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.