Mechanistic analysis and significance of sphingomyelinase-mediated decreases in transepithelial CFTR currents in nHBEs.

Physiol Rep · 2021 · PMC8436056 · PMID 34514718

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almost significantlyno p-value reported

Interestingly, WT SMase treatment also increased the dh16:0 dihydroceramide in nHBEs, and almost significantly increased the dh24:1 dihydroceramide (Figure 3d ).

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did not reach statistical significanceno p-value reported

Note that while this trend remained in the VX770‐potentiated and INH172‐sensitive currents, the results did not reach statistical significance, likely due to a smaller number of replicates.

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