Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and meta-analysis of clinical trial studies.

Though former meta-analyses and large prospective cohorts have pointed out serious infection among the most prevalent adverse events associated with TCZ therapy [ 34 , 52 – 54 ], our meta-analysis also showed that this adverse event was lower in patients receiving TCZ than in the control group, but the difference did not reach statistical significance.

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