Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression.

In contrast, there was a marked and highly significant ( p <0.01) reduction in Y705 phosphorylated STAT3 by OLT1177 (82%) and AZD1480 (80%) compared to vehicle ( Figures 2C, D ).

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Western blot analysis of the primary tumors revealed that treatment with either OLT1177 or AZD1480 reduced constitutive STAT3 levels by 31% and 29%, respectively, but did not reach statistical significance ( Figure 2B ).

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