High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1).

A moderate but statistically significant increase in MBNL1 protein was observed ( S6A and S6B Fig ); the smaller increase seen in DMPK mRNA did not reach statistical significance ( S6D Fig ).

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