A genome-wide association study of the frailty index highlights brain pathways in ageing.

Aging Cell · 2021 · PMC8441299 · PMID 34431594

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0180

boldest claim

The sentences

close to significancep = 3*10 −7actually significant

rs61348208 is associated with parents’ lifespan (RHJ Timmers et al., 2019 ) and is close to significance in this analysis ( RBM6 locus, p = 3*10 −7 ) though still not reaching the genome‐wide cut‐off (5*10 −8 ).

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nominally significantp = 0.018actually significant

First, the previous GWAS of FI (Mekli et al., 2018 ) identified 2 variants; however, neither were associated with FI: rs6765037 ( p = 0.410), although rs7134291 was nominally significant ( p = 0.018).

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