The antagonistic pleiotropy of insulin-like growth factor 1.

Aging Cell · 2021 · PMC8441393 · PMID 34363732

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hedged sentences

1.0000

closest p · 20.0× alpha

1.0000

boldest claim

The sentences

highly significantp < 1not close (p > 0.1)

Consistent with our stratified analyses, we found the directions of clinical event hazards associated with these terms to be highly significant and consistent in direction for both the age‐interaction (mortality p < 1 0 ‐ 13 ; dementia p = 0.004 ; vascular disease p < 1 0 ‐ 5 ; osteoporosis p < 0.001 ; diabetes p < 1 0 ‐ 17 ) and U‐shape effect terms (mortality p < 1 0 ‐ 96 ; dementia p < 1 0 ‐ 7 ; vascular disease p < 1 0 ‐ 17 ; osteoporosis p < 1 0 ‐ 23 ; diabetes p < 1 0 ‐ 165 ).

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nominally significantno p-value reported

The results were also similar when stratified by sex (Figures S13 and S14 ), with some associations becoming only nominally significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.