Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value.

2 ). Although sACE2 levels, considered a continuous variable, showed a significant value for predicting secondary events ( p = 0.030) and the combination of MACE ( p = 0.030) by the univariate Cox regression tests in the HF cohort, they did not reach statistical significance in the multivariate regression models for long-term prognosis adjusted by age, gender, diabetes mellitus, reduced GFR and reduced LVEF.

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