Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line.

The expression of MPG in the APEX1 null lines tended to be lower but this decrease did not reach statistical significance ( S4 Fig ), so it is unlikely that extra AP sites do not appear due to the lack of adduct excision by the glycosylase.

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