Sleep Deprivation Disturbs Immune Surveillance and Promotes the Progression of Hepatocellular Carcinoma.

Compared to the group without SD (Con), CD3 + T cells in the blood of CSD mice showed an increasing trend, although the difference was non-significant.

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The percentage of CD4 + T cells ( Figure 1D ) and CD4/CD8 ratio ( Figure 1F ) were higher, whereas the percentage of CD8 + T cells showed a decreasing trend after ASD ( Figure 1E ), although the difference was non-significant.

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Tumor volume ( Figure 3B ) and weight ( Figure 3C ) were significantly increased in the CSD + T + CSD group compared to the T group (both p < 0.05) and were also higher in the T + CSD group compared to the T group, although the difference did not reach statistical significance.

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