It is worth to comment that encapsulation of molecules in the cavity of CDs forming inclusion complexes does not necessarily favor the solubility of the drug since the supramolecular structures resulting from this process can exhibit a significant trend to aggregate, eventually forming a precipitate or even leading to exotic structures in aqueous solution [11] .
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Aggregation versus inclusion complexes to solubilize drugs with cyclodextrins. A case study using sulphobutylether-β-cyclodextrins and remdesivir.
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