The Effects of Repetitive Use and Pathological Remodeling on Channelrhodopsin Function in Cardiomyocytes.

Pathological hypertrophy, as induced by PE treatment, had no effect on average I peak,rel values, whereas the effect of pulse train rate was highly significant for each ChR variant ( Figure 3B ).

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The inactivation kinetics of ReaChR and GtACR1 were not affected by 1-Hz preconditioning, but while the former showed a trend of deceleration, the latter showed acceleration with higher pulse rates ( Supplementary Figures 6D, 7I and Supplementary Table 2 ).

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