Although the NestinCre ERT2 ;Tlx flx/flx mice showed a trend for increased ambulatory behaviour, these did not reach significance (NestinCre ERT2 ;Tlx flx/flx vs Tlx flx/flx , mean speed: 0.077 ± 0.016 vs 0.061 ± 0.06 m/s, p = 0.14 in Fig. 4 B; line crossings: 357 ± 29 vs 300 ± 13, p = 0.05 in Fig. 4 C).
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Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain.
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