Association of central arterial stiffness with hippocampal blood flow and N-acetyl aspartate concentration in hypertensive adult Dahl salt sensitive rats.

An association between SBP and aPWV in the above clinical studies is in agreement with the finding in our cross-sectional study that SBP correlated positively with aPWV with borderline significance (Fig. 3 ).

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Bivariate analysis revealed a positive borderline correlation between aPWV and SBP with a near-significant P -value of 0.06 and an R 2 value of 0.31 (Fig. 3 ).

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For over two decades, epidemiological and clinical studies have shown strong associations between vascular risk factors and dementia [ 1 – 5 ], indicating that diseases of the vascular wall, that is, stiffening of the arterial wall and hypertension, may be significant contributors to vascular dementia [ 6 – 11 ].

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