Polypharmacy as maintenance treatment in bipolar illness: A systematic review.

Acta Psychiatr Scand · 2021 · PMC8453557 · PMID 33960396

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did not reach statistical significanceno p-value reported

16 The other studies, 2 RCTs and 1 observational study, 12 , 13 , 14 consistently suggest some advantages in terms of time to mood relapse or treatment failure in the combination treatment group (hazard ratio, HR, between 0.72 and 0.80), although these results did not reach statistical significance.

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a trend toward significanceno p-value reported

21 However, a trend toward significance was found in time to manic or mixed episode (HR = 0.6) and time to any episode (HR = 0.7), in favor of the combination treatment.

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