Barely Significant
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Combination of Metformin and Exercise in Management of Metabolic Abnormalities Observed in Type 2 Diabetes Mellitus.

Diabetes Metab Syndr Obes · 2021 · PMC8453852 · PMID 34557007

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showed a trendno p-value reported
On the contrary, Konopka et al 20 showed a trend but not significant decrease in basal AMPK following 12 weeks of aerobic exercise training, in metformin naïve older adults at risk of T2DM.

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