Morphine females tended to show enhanced hyperalgesia (shorter latencies) compared with morphine males in the tail withdrawal assay, although this result did not reach statistical significance ( Fig. 8 B ; p = 0.07).
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Sex Differences in Behavioral and Brainstem Transcriptomic Neuroadaptations following Neonatal Opioid Exposure in Outbred Mice.
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In females, highly significant enrichment terms were identified for 25 ribosomal genes and several genes coding for mitochondrial proteins and oxidative phosphorylation, all of which were upregulated in response to morphine.