Postmortem Metabolomics: Strategies to Assess Time-Dependent Postmortem Changes of Diazepam, Nordiazepam, Morphine, Codeine, Mirtazapine and Citalopram.

Based on this, one would expect a very similar time-dependent postmortem behavior of the drugs; however, as detailed above, while morphine and codeine overall do not show significant concentration changes over time, mirtazapine does show an overall trend towards time-dependent concentration increases, similar to citalopram.

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In contrast, the two studied antidepressants mirtazapine ( n = 55) and citalopram ( n = 50) showed a trend for time-dependent concentration increases with a median of +82% and +25%, respectively as displayed in Figure 1 (mirtazapine: min −95%, max +960%; citalopram: min −95%, max +3900%).

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