Pilot Study of Anti-Th2 Immunotherapy for the Treatment of Breast Cancer-Related Upper Extremity Lymphedema.

Biology (Basel) · 2021 · PMC8466465 · PMID 34571811

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not quite reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

The number of CD4 + IL4 + cells was also decreased; however, this difference did not quite reach statistical significance ( p = 0.06).

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did not reach statistical significanceno p-value reported

Treatment with QBX258 decreased type I collagen deposition to near-normal levels in the papillary and reticular dermis in the lymphedema limb biopsy specimens (but did not change type I collagen expression in the skin of the unaffected limb [not shown]); however, there was some variability in this response, but these changes did not reach statistical significance ( Figure 4 a,b).

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