Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in Woodchucks.

The relapse in WHsAg also appeared delayed, but the difference to Group 7 did not reach statistical significance. 3.3. hzVSF Minimally Reduced WHV Replication and Antigen Expression in the Liver of Woodchucks, but the Antiviral Effect Was Pronounced in Combination with TAF and Durable in a Subset of Animals Placebo treatment of chronic WHV carrier woodchucks (Group 3) had no effect on viral DNA RI, cccDNA, and RNA, and on cytoplasmic WHcAg and membranous WHsAg expression in the liver ( Figure 9 a and Figure 10 a, Figures S2a–S6a ).

also in 111,027 other papers