Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice.

This variability made quantification of the results challenging and differences between nTNFR2KO and TNFR2ff controls, while showing a trend towards increased death in the CA3 region of nTNFR2KO mice, did not reach statistical significance (Fig. 6 Cii).

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