Among the structural modifications explored, there appears to be a clear trend, as the presence of a methyl or methoxy substituent in the condensed phenyl ring of all scaffolds (29, 32–34) seems to be detrimental for activity, while both modifications explored at the level of the five-membered condensed ring (furan or pyrrole) are tolerated.
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Structure-Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections.
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