Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery.

In addition, cluster B patients showed a trend towards superior spike (S1)-, nucleocapsid (N)- and membrane (M)-specific T cell responses as enumerated by IFN-γ or IL-2 spots forming units (SFU)/10 6 PBMCs ( Figure 5 H), and cluster B accumulated significantly more patients with ≥15 S1-specific IFN-γ SFU/10 6 PBMC than cluster A ( Figure 5 I), suggesting that cluster B patients had a more robust SARS-CoV-2-specific cellular immune response as early as a week after symptom onset.

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