only marginally significantP = 0.067
Decreasing Ccr showed an adverse effect in univariate analysis (HR 2.14, 95% CI 1.22–3.77 P = 0.008), but this association was only marginally significant in multivariate analysis with adjusted HR 1.90 (95% CI 0.96–3.77, P = 0.067) (Table 2 ).