Thiazide diuretics and the rate of disease progression in autosomal dominant polycystic kidney disease: an observational study.

Nephrol Dial Transplant · 2021 · PMC8476080 · PMID 33150452

Europe PMC DOI

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0.1000

closest p · 2.0× alpha

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boldest claim

The sentences

near-significantP = 0.1so close (0.05 < p ≤ 0.1)

Here we found a near-significant interaction term for 24-h urine volume and use of thiazides (P = 0.1): in patients with urine volume <2200 mL ( n = 226), use of thiazides was associated with a lower risk of the composite kidney endpoint [HR 0.35 (95% CI 0.16–0.77); P = 0.009], while there was no association in patients with urine volume >2200 mL [ n = 238; HR 1.48 (95% CI 0.75–2.91); P = 0.3].

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