Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.

Conditioning on this common variant rs3817928, the joint test of gene-by-current-smoking analysis for GPR126 remained nominally significant in the discovery ( p -value = 2.4E−03) and genome-wide significant in the replication studies ( p -value = 3.9E−09 in UK BiLEVE and p -value = 9.6E−17 in UK Biobank, Table 3 ).

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SNV rs17280293 is in low linkage disequilibrium (LD) with the previously reported common variant rs3817928 in GPR126 (R 2 = 0.13 based on 1000 Genomes database Phase 3 27 ), thus rs17280293 remained highly significant in the single-variant-based analysis when conditioning on rs3817928 (Table 3 ).

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