Splenic CD8 + T cells elicited by Spike-p(Man-TLR7) vaccination trended towards increased intracellular cytokine expression relative to mice treated with Spike alone, but did not reach statistical significance ( Fig. 5 C and D; Fig.
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Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant.
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