Therapeutic Challenges and Emerging Treatment Targets for Pulmonary Hypertension in Left Heart Disease.

60 Although epoprostenol resulted in a significant increase in cardiac index, decrease in PAWP, and decrease in systemic vascular resistance, the study was stopped early because of a strong trend toward decreased survival with epoprostenol. 60 The majority of death events were caused by progressive congestive heart failure, with the hypothesis that vasodilators could result in short‐term benefit but activate deleterious neurohormonal systems and lead to renin secretion in the longer term. 6

also in 5,725 other papers