Intrathymic differentiation of natural antibody-producing plasma cells in human neonates.

Nat Commun · 2021 · PMC8486820 · PMID 34599177

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did not reach statistical significanceno p-value reported

The frequency of IGHV rearrangements with somatic mutations appeared higher in thymic CD21 − CD35 − CD138 + plasma cells compared to total CD21 - CD35 - or CD35 + CD35 + B cells, although this difference was mostly observed for the 3- and 4-month-old thymus specimens, and did not reach statistical significance (Fig. 6c ).

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