Critical timing of ACEi initiation prevents compensatory glomerular hypertrophy in the remaining single kidney.

If ACEi was started four days before uni-Nx, both kidney weight and GV were reduced at 14-days post-uni-Nx, but did not reach statistical significance.

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Therefore, the timing of ACEi intervention in relation to the uni-Nx event had a highly significant long-term effect on the degree of compensatory GV enlargement by 40 weeks post-uni-Nx.

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