Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.

Compared to WT littermates, RNF213 KO animals were also more likely to lose more bodyweight and reach the ethical endpoint following challenge with a mouse-adapted strain of RSV even though the difference in lung virus loads determined on day 5 after infection did not reach statistical significance (Supplementary Fig. 12e-g ).

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