However, a sex difference was apparent when examining the total alcohol consumed in a 2 versus 3-bottle choice paradigm: male C57BL/6J mice drank less alcohol when it was presented alongside nicotine, whereas female C57BL/6J mice consumed the same amount of alcohol with or without concurrent nicotine access ( O’Rourke et al., 2016 ).
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Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors.
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