Distinct mutational profile and immune microenvironment in microsatellite-unstable and <i>POLE</i>-mutated tumors.

10.1136/jitc-2021-002797.supp4 Supplementary data In the analyses of the relationship between the immune cell infiltration, TMBs and indel mutations, the number of indel mutations was strongly correlated with all examined types of immune cell (CD3+, CD4+, CD8+, FoxP3+ and PD-1+) densities (R=0.61–0.72, p≤0.002) ( figure 5H–L ), whereas the total number TMB was not significantly associated with all examined immune cell densities (R=0.23–0.38); only CD3-positive and CD4-positive T-cell densities showed borderline significance (p=0.072 for both cases) ( figure 5M–Q ).

also in 7,017 other papers

CD3-positive, FoxP3-positive and PD-1-positive immune cell densities were also increased in the MSI-high tumors, although the increase did not reach statistical significance ( figure 5A–G ).

also in 111,027 other papers