Pro-resolving lipid mediator lipoxin A₄ attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome.

In particular, we observed a strong trend toward reduction in the severity of the disease between the LXA 4 -prophylactic-treated mice and the vehicle-treated mice ( Figure 1D ; Tables S1 and S2 ).

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Overall, these results indicated that the production of specific cytokines that characterize the main pro-inflammatory T cell subsets from control or patients with MS was significantly reduced or showed a trend toward significance upon pre-treatment with LXA 4 , indicating that LXA 4 regulates human T cell responses as well as their transmigration capacity.

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