Interestingly, although additional changes did not reach statistical significance, expression of many different miRNAs was generally decreased in the HIV/lipo group as observed by the left shift in the base of the volcano plots shown in Figure 2A and the bluish tone of the upper half column for HIV/lipo in the heatmap displayed in Figure 2B .
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Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways.
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