Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin).

In order to validate the presence of IFN-γ cytokine that could induce this pattern of gene expression by the tumor cells, we tested whole tumor lysates with an IFN-γ ELISA (data not shown); this showed a trend for more IFN-γ in tumor-bearing mice compared with healthy brains, presumably derived from infiltrating T cells and NK cells.

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