Ibrutinib reduces neutrophil infiltration, preserves neural tissue and enhances locomotor recovery in mouse contusion model of spinal cord injury.

Over four weeks, immediate and double-injection groups considerably showed a trend of increase in BMS scores that become significantly different compared to the control (vehicle treatment) group ( P <0.01).

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Subsequently, an increasing trend in body weight was observed in the control and sham groups during 4 weeks following SCI, however, ibrutinib administration immediately or 12-hour after SCI slowed this increasing trend.

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