OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice.

Epithelial-specific TNFR1 ablation generally suppressed the upregulation of cytokines and chemokines in the skin of OTULIN E-KO mice, although the differences between the groups did not reach statistical significance due to the large variability of the values between individual mice (Fig. 2e ).

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