Mann Whitney analyses showed a highly significant correlation of gonadotropin-stimulated BTV with the presence of homozygous or hemizygous variants compared to heterozygous or WT patients ( p = 0.007 and p = 0.01 at 18 or 24 months, respectively) (Table 1 ).
Kruskal–Wallis tests used to investigate if total testosterone values, PSA values, SDS height change from previous evaluation, growth rate, growth in BTV, increase in penile length, were associated with a specific weekly dosage of gonadotropins (and specifically to hCG) found that: (1) as expected T levels were strictly associated with the weekly dosage of hCG ( p < 0.0001); (2) PSA also showed a trend to significance in the association with the weekly dosage of hCG ( p = 0.06); (3) the administration of hCG, but not the dosage used, was found to be associated with a significant increment of height ( p = 0.001); (4) the administration of hCG, but not the dosage used, was found to be associated to a significant increment of BTV ( p = 0.002) and penile length ( p = 0.007) after 6 months.