Programmed death ligand 1 (PD-L1) in colon cancer and its interaction with budding and tumor-infiltrating lymphocytes (TILs) as tumor-host antagonists.

Int J Colorectal Dis · 2021 · PMC8505298 · PMID 34170390

Europe PMC DOI

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0.0010

closest p · 0.0× alpha

0.0840

boldest claim

The sentences

highly significantp < 0.001actually significant

Higher amounts of TILs were significantly correlated with female gender ( p = 0.002), less L1 ( p = 0.001), and less V1 ( p = 0.001) and correlated highly significant with lower pT ( p < 0.001), pN ( p < 0.001), and M stages ( p < 0.001), as well as nonmucinous (NOS) CC ( p < 0.001) and lower TNM stages ( p < 0.001).

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showed a trendp = 0.084so close (0.05 < p ≤ 0.1)

Differences between the four groups were statistically significant for DFS and OS between the low budding/high TIL group and the low budding/low TIL group ( p = 0.027 for DFS and p = 0.023 for OS) as well as between the low budding/high TIL group and the high budding/low TIL group ( p = 0.004 for DFS and p = 0.005 for OS) and showed a trend to longer OS for low budding/high TILs versus high budding/high TILs ( p = 0.084).

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