These immunoblotting data indicate that the incubated cocaine-craving observed under the present self-administration procedures is associated with a strong trend towards a PL-selective reduction in mGlu1 and mGlu5 expression and that acute, oral, dosing with 1.0 mg/kg everolimus is sufficient to reverse these neuroadaptations within the PL and to augment mGlu1 dimer expression also within the IL.
← all excerpts
Preclinical evidence to support repurposing everolimus for craving reduction during protracted drug withdrawal.
1
—
—