The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma.

However, although the numbers of patients are limited, the association between the detection of the three proteins and prognostic is clearly significant (Fig. 3c ).

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In particular, groups of comparable sizes showing a highly significant difference in survival probabilities were obtained by stratifying the patients into two groups: 0 or 1 activated genes corresponded to the longest survival probability (“good” prognostic) whereas 2- or 3-gene activations predicted shorter survival probability (“poor” prognostic) (Fig. 1c , right panel).

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