Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Consistently, differential gene expression among TCGA showed a trend for both TSP-1 and CD47-encoding genes (i.e., THBS1 and CD47 , respectively) to be upregulated in ovarian carcinoma patients ( Figure 2 d), especially with elevated THBS1 mRNA expression in case of vascular and lymphovascular invasion ( Figure 2 e).

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