Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling.

We found that while the GLAST + neural precursors showed a trend of increasing, the β3-Tubulin + cells increased significantly in the treated group compared with the control ( Figure 5 J,K,P,Q) (number of GLAST + cells per 2 mm of cross-sectioned meninges: CTRL = 9.667 ± 0.3333, n = 3; FLUOX = 12.67 ± 2.848, n = 3; p = 0.3545; number of β3-Tubulin + cells per 2 mm of cross-sectioned meninges: CTRL = 15.67 ± 2.848, n = 3; FLUOX = 31.19 ± 3.641, n = 3; p = 0.0284).

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We observed an increasing trend of CD68 + cells in meninges of fluoxetine-treated mice, although the difference was not statistically significant ( Figure 5 M,S).

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