Fold reduction of antibody binding to RBD-E484K mutant was higher in serum and nasal wash from symptomatic COVID-19 patients (3.45- and 2.81-fold, respectively) compared with reduction in binding in asymptomatic serum and nasal wash (2.1 and 1.91, respectively), but these differences did not reach statistical significance ( Fig. 3C ).
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Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2-infected individuals reveal unlinked immune signatures.
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