The global trends and regional differences in incidence and mortality of hepatitis A from 1990 to 2019 and implications for its prevention.

Conclusion There is an unfavorable trend that hepatitis A is still pending in hyperendemic regions and is emerging in low endemic regions.

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The ASIRs were deemed in an increasing trend in 65 countries or territories, with the largest increase in Thailand (EAPC = 1.35; 95% CI 0.99 to 1.71), followed by Japan and Germany (Fig. 1 C and Table S2).

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The remaining 65 countries or territories showed a decreasing trend in ASRs, with the highest decrease in Belarus (EAPC = −0.76; 95% CI −0.89 to −0.64), followed by Argentina and Romania (Fig. 1 C and Table S2).

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