Association of peripheral blood DNA methylation level with Alzheimer's disease progression.

For the probe annotated to GABBR1 among the top 1000 DMPs associated with MCI to AD conversion status in the AddNeuroMed study (cg06512249, β = − 0.03, P = 0.003), the direction was consistent with multiple probes in the same region from this study (cg03316098, β = − 0.05, P = 0.01; cg10234998, β = − 0.10, P = 0.005; cg12061917, β = − 0.07, P = 0.001; cg21481950, β = − 0.06 P = 0.007) even though cg06512249 did not reach the nominally significant threshold in this study ( P > 0.05) (Additional file 1 : Fig. 8E).

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