Valproic Acid Enhanced Temozolomide-Induced Anticancer Activity in Human Glioma Through the p53-PUMA Apoptosis Pathway.

Interestingly, in our analysis, the benefit of long-term VPA treatment did not reach statistical significance in either the seizure or no-seizure group but in the combined group ( Supplementary Table S3 ), indicating that the presence or absence of seizures does not significantly impact the effect of VPA.

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