Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.

Alzheimers Dement · 2021 · PMC8519060 · PMID 33797837

Europe PMC DOI

hedged sentences

0.0080

closest p · 0.2× alpha

0.0080

boldest claim

The sentences

nominally significantP = 0.008actually significant

Notably, rs192471919 had a nominally significant association ( P = 0.008), with same effect direction in Jansen et al. 3 where it was present only in the PGC-ALZ cohort (n = 16,350).

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highly significantno p-value reported

The most highly significant SNV-associated meta-analysis gene was LINC00298 .

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